Montoya & Lerner Protocols
Antiviral Therapy Protocol
The Stanford double-blind trial roadmap for Valcyte (valganciclovir), Famvir, and Valtrex targeting chronic herpesvirus reactivation.
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Clinical Directory
32 Monograph Protocols
Clinical Treatment Protocols for ME/CFS, Long COVID & Dysautonomia
An organized, evidence-based compendium of pharmacological regimens, microglial modulators, hemodynamic stabilizers, and bioenergetic therapies compiled from leading post-viral neuro-immune clinics.
1. Antivirals & Immunotherapy
Targeting persistent herpesvirus reactivation (EBV, HHV-6), enteroviruses, SARS-CoV-2 viral reservoirs, and autoimmune neuro-inflammation.
Renal Dosing & Bioavailability
Valacyclovir vs Acyclovir vs Valganciclovir
Pharmacokinetic bioavailability comparison, PEPT1 intestinal uptake, and renal Cockcroft-Gault dosing calculator.
Read Clinical Protocol →Viral Reservoir Suppression
Paxlovid in Long COVID & ME/CFS
Extended 15-day nirmatrelvir/ritonavir protocols targeting persistent gut and tissue SARS-CoV-2 viral reservoirs.
Read Clinical Protocol →NK Cell Cytotoxicity & Th1
Inosine Pranobex (Imunovir / Isoprinosine)
Pulsed immunomodulation protocol to restore deficient Natural Killer cell cytotoxicity and shift helper T-cell balance.
Read Clinical Protocol →Autoantibody Neutralization
IVIG Protocol: Dosing & Neuropathy
High-dose immunomodulatory vs low-dose replacement IVIG for small fiber neuropathy, GPCR autoantibodies, and hypogammaglobulinemia.
Read Clinical Protocol →TLR7/9 Endosomal Inhibition
Hydroxychloroquine (Plaquenil) in ME/CFS
Toll-like receptor 7/9 down-regulation, autoantibody attenuation, and retinal screening monitoring guidelines.
Read Clinical Protocol →2. Neuro-Immune & Microglia Modulation
Dampening central microglial activation, neuro-inflammation, and cholinergic anti-inflammatory signaling.
Endorphin Rebound & TLR4
Low-Dose Naltrexone (LDN) Clinical Guide
Master clinician guide on mechanism of action, microglial antagonism, compounding methods, and troubleshooting.
Read Clinical Protocol →Micro-Titration & Dilution Tool
LDN Micro-Titration Protocol: 0.5 to 4.5 mg
Conservative 12-week schedule generator, water dilution recipe (50 mg into 50 mL), and sleep optimization tips.
Read Clinical Protocol →Stanford Clinical Discovery
Low-Dose Abilify (LDA) Protocol
Drs. Montoya and Crosby discovery: presynaptic dopamine D2/D3 partial agonism calming neuro-inflammatory crashes.
Read Clinical Protocol →0.1 to 2.0 mg Dosing Calculator
Low-Dose Aripiprazole Microglial Reset
Liquid aripiprazole micro-titration schedule generator, receptor pharmacology, and paradoxical flare avoidance.
Read Clinical Protocol →Alpha-7 nAChR Agonism
Nicotine Patch Protocol for Long COVID & ME
The Leitzke cholinergic hypothesis: displacing bound spike proteins and activating microglial calming pathways.
Read Clinical Protocol →Patch Cutting & Dose Tool
Transdermal Nicotine Patch Titration Guide
Matrix patch cutting safety rules, 3.5 mg to 7 mg step-up calculator, and Herxheimer reaction mitigation.
Read Clinical Protocol →3. Dysautonomia, POTS & Hemodynamics
Expanding intravascular circulating volume, improving cerebral blood flow, and suppressing excessive orthostatic tachycardia.
Comprehensive Hemodynamic Map
Dysautonomia & POTS Clinical Protocol
Stepwise pharmacotherapy ladder: volume expansion, vasoconstrictors, sinus node blockers, and central alpha-agonists.
Read Clinical Protocol →Mineralocorticoid Therapy
Fludrocortisone (Florinef) & Desmopressin
Renal sodium retention protocols, potassium monitoring rules, and DDAVP antidiuretic hormone management.
Read Clinical Protocol →Comparative Prescribing Matrix
Fludrocortisone vs Midodrine vs Ivabradine
Choosing between volume expansion, alpha-1 vasoconstriction, and selective hyperpolarization-activated HCN channel blockade.
Read Clinical Protocol →I_f Channel Inhibition
Ivabradine (Corlanor) & Beta-Blockers
Controlling postural tachycardia without dropping blood pressure or triggering bronchial constriction in asthma/MCAS.
Read Clinical Protocol →Acetylcholinesterase Inhibition
Pyridostigmine (Mestinon) Protocol
Enhancing parasympathetic vagal neurotransmission, splanchnic venous return, and exercise capacity in pre-load failure.
Read Clinical Protocol →Microvascular Endothelial Rescue
Fibrinolytic Enzyme Protocol
Nattokinase, lumbrokinase, and serrapeptase dosing protocols to break down amyloid fibrin microclots and restore capillary perfusion.
Read Clinical Protocol →4. Mitochondrial, Methylation & MCAS
Rescuing the electron transport chain, unblocking the folate-methionine cycle, and stabilizing enteric mast cells.
Folate-Methionine Cycle
Simplified Methylation Protocol
Rich Van Konynenburg protocol: hydroxycobalamin, methylfolate, and adenosylcobalamin restoring cellular transmethylation.
Read Clinical Protocol →Master Cellular Antioxidant
Glutathione Depletion & Synthesis Guide
Liposomal glutathione, NAC, and whey bioactive peptides restoring inner mitochondrial antioxidant defenses.
Read Clinical Protocol →ATP Bioenergetics
Mitochondrial Support & ATP Production
Co-factor cocktail targeting Complexes I through V: alpha-lipoic acid, acetyl-L-carnitine, magnesium malate, and riboflavin.
Read Clinical Protocol →Electron Transport Synergy
CoQ10 & NADH Synergy Protocol
Castro-Marrero randomized trials: combined CoQ10 + NADH reducing post-exertional fatigue scores and resting heart rate.
Read Clinical Protocol →Pharmacokinetic Absorption
Ubiquinol vs Ubiquinone Absorption Guide
Plasma CoQ10 target levels (> 2.5 mcg/mL), lipid-solubilized softgels, and dosing conversion calculator.
Read Clinical Protocol →Sublingual Absorption
Sublingual NADH & Cellular ATP Protocol
Bypassing gastric acid destruction via stabilized oral sublingual delivery directly into systemic micro-circulation.
Read Clinical Protocol →NAD+ Salvage Pathway
Nicotinamide Riboside & NAD+ Precursors
NR vs NMN vs flush niacin: sirtuin activation, PARP enzyme consumption, and methyl donor preservation rules.
Read Clinical Protocol →Adenine Nucleotide Recovery
D-Ribose Pentose Phosphate Protocol
Teitelbaum clinical trial: 5g TID pure D-ribose bypassing the rate-limiting G6PD step to replenish degraded cellular ATP pools.
Read Clinical Protocol →Fatty Acid Beta-Oxidation
Acetyl-L-Carnitine vs L-Carnitine
Shuttling long-chain fatty acids into mitochondria: ALCAR for cerebral cognitive fog vs L-carnitine fumarate for muscle fatigue.
Read Clinical Protocol →Systemic Mast Cell Stabilization
Mast Cell Activation Syndrome (MCAS) Protocol
Comprehensive 4-tier pharmacotherapy ladder: H1/H2 blockers, cromolyn, ketotifen, leukotriene inhibitors, and low-histamine diet.
Read Clinical Protocol →Dual-Receptor Blockade
H1 & H2 Antihistamine Stacking Protocol
Dosing synergy: stacking second-generation H1 antagonists (fexofenadine, cetirizine) with H2 antagonists (famotidine) to prevent POTS vasodilation.
Read Clinical Protocol →Systemic vs Luminal Stabilizers
Ketotifen vs Cromolyn Sodium for MCAS
Selecting the right stabilizer: blood-brain barrier penetrating ketotifen for neuro-MCAS vs non-absorbed oral cromolyn for gastrointestinal symptoms.
Read Clinical Protocol →Enteric Histamine Degradation
DAO Enzyme & Quercetin Phytosome
Exogenous diamine oxidase enzyme timing, bio-enhanced quercetin phytosome dosing, and histamine breakdown in the gut lumen.
Read Clinical Protocol →Historical Pioneer Archive
Dr. Paul Cheney Clinical Protocols
Preserved clinical archive of Dr. Paul Cheney: diastolic heart failure, cellular oxygen toxicity, cell-signaling factors, and bovine colostrum.
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