Treating Chronic Fatigue Syndrome (ME/CFS): Amantadine

Amantadine is an antiviral and central nervous system stimulant that inhibits viral infection of the cell and increases dopaminergic activity in the brain.

Amantadine was first approved to treat the Asian flu (Influenza A) but was subsequently found to assist in the treatment of muscle stiffness and muscle control in Parksinson's and in the treatment of carbon monoxide poisoning. Amantadine improves fatigue and muscle control and reduces muscle stiffness in some multiple sclerosis (MS) patients. Its most common use to short-term treatment of the flu.

Amantadine interferes with a viral protein needed to 'uncoat' a virus once it enters the cell. Amantadine's mode of action in the central nervous system is unclear but appears to involve increased dopamine and perhaps norepinephrine release.

Amantadine May Be Helpful in Chronic Fatigue Syndrome (ME/CFS) because of its antiviral activities and because it may enhance the activity of a part of the central nervous system (dopaminergic functioning) that may be underactive in chronic fatigue syndrome (ME/CFS). Amantadine can effect several symptoms (fatigue, muscle stiffness) found in ME/CFS/FM.

Chronic Fatigue Syndrome (ME/CFS) Studies   - Amantadine was poorly tolerated by ME/CFS patients and showed little benefit in a cross-over study with carnitine.

Chronic Fatigue Syndrome (ME/CFS) Doctors Report  - Over a small sampling of patients Dr. Bell found that 40% could not tolerate the drug (mostly due to jitteriness and anxiousness) and 40% reported from moderately improved to excellent results. Amantadine seemed to be most effective in treating moderately ill patients. Dr. De Meirleir reports Amantadine relieves fatigue in some ME/CFS patients.

Dose - Dr. Bell reports that the standard dose of 100 mg twice daily causes jitteriness and exacerbates symptoms in ME/CFS. He starts at half a teaspoon a day (25 mgs.) and works his way up to 50 mgs.

Side effects   - Amantadine is reportedly generally well tolerated (but seems to be less so in ME/CFS overall). Side effects can include dizziness, trouble sleeping, nausea. Rare side effects include shortness of breath, swelling of hands and feet, nervousness, anxiety, difficulty in concentrating, and exacerbations of pre-existing seizure disorders and psychiatric symptoms, etc. Very rare cases of suicide attempts have been reported in people without psychiatric symptoms taking short-term courses of Amantadine for the flu.


The Phoenix Rising website is compiled by a layman with ME/CFS. It is not a substitute for a physician and is for informational uses only. It does not present complete information on this drug. Please discuss any treatments
in these pages with your doctor.

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Bell, David, MD. 1999. Clinical Experience- The Use of Amantadine in Chronic Fatigue Syndrome. Lyndonville News

Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology. 1997;35(1):16-23.

Drugs.com: Amantadine

Wikipedia: Amantadine