Treating Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia: The Cellular Energy
Producers - D-Ribose
"Ribose is a unique and powerful addition to our complement of metabolic
therapies. For those suffering from fatigue, muscle soreness, stiffness and a
host of related medical complications the relief ..can be life changing"
Jacob Teitelbaum M.D.
What It Is D-ribose is an important structural
component of many of the components (DNA, RNA, ATP, FADH, coenzyme-A, and NADH)
needed by the mitochondria to keep the cells supplied with energy.
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What D-Ribose Does D Ribose provides a key building block in the production of cellular energy.
Studies have shown that D-ribose increases physical functioning overall,
exercise tolerance, diastolic functioning and quality of life in congestive
heart failure patients. It has also been used to restore energy levels after
intense exercise.
D-Ribose May Work in Chronic
Fatigue Syndrome (ME/CFS) Because it increases energy production in the
heart and muscles. Dr. Cheney reports low heart functioning (diastolic
dysfunction) is present in many of his chronic fatigue syndrome patients.
Several physicians including Dr. Teitelbaum, Dr. Myhill and Dr. Cheney believe
that low cellular energy production plays a key role in chronic fatigue
syndrome (ME/CFS).
Evidence A study by Dr. Teitelbaum found that D-ribose
produced by CORvalen (one scoop (5 g) of
CORvalen three times a day with food or liquids) resulted in significant
improvement in sleep patterns, energy levels, mental clarity, pain threshold and
well-being in ME/CFS patients. A closer look shows that these patients were
helped but were not cured; on a scale of 1-10 their energy levels increased from
3.8-5.5, sleep from 4.8-6.0, mental clarity from 4.9-5.7, pain from 4.9-5.6 and
well-being from 4.3-5.6. Dr. Teitelbaum noted that a 45% increase in energy from
one supplement was amazing. A few side effects were experienced by a small
number of patients and these were eliminated by lowering the dose.
Dose Dr. Teitelbaum reports it is critical to use the
proper dose (5 grams three times a day) for the first three weeks. A
CORvalen representative I talked to recommended that ME/CFS patients take the
normal dose for a month or so and then cut back to two scoops a day if they
wished. It often takes several weeks for ME/CFS patients to determine if its
working. He reported that Dr. Cheney began using CORvalen in the middle of 2006.
Dr. Teitelbaum is currently working in a larger placebo-controlled D-Ribose
study in ME/CFS.
Cellular Energy
Producers in Chronic Fatigue Syndrome (ME/CFS)
(This and all
sections of the Phoenix Rising website are compiled by a layman. They are not a
substitute for a physician and are for informational uses only. Please discuss
any treatments in these pages with your physician.)
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The IACFS Conference Proceedings of 2007
Jacob Teitelbaum, M.D. 2007. From Fatigued to Fantastic. Avery Publishers.