Bridging two decades of pioneering patient advocacy with contemporary post-viral immunology. Deciphering the shared physiological pathophysiology of classic ME/CFS and Long COVID: cellular mitochondrial failure, Post-Exertional Malaise (PEM), autonomic dysregulation (POTS), and persistent neuro-immune exhaustion.
Explore restored and expanded monographs cited across international medical literature, academic conferences, and patient communities.
The 4-part legal and medical roadmap: SSDI/ERISA functional standards, 2-day CPET testing documentation, Residual Functional Capacity (RFC) forms, and Administrative Law Judge (ALJ) appeal strategies.
Read Disability Series →In-depth analysis of Dr. Richard Van Konynenburg's simplified protocol, MTHFR mutations, bioactive cobalamin (hydroxo/methyl B12), methylfolate (5-MTHF), and cellular SAMe synthesis.
Explore Methylation Protocols →Intracellular glutathione (GSH) depletion, Dr. Martin Pall's NO/ONOO- peroxynitrite cascade, cerebral lactic acid elevation, and oral liposomal vs. nebulized vs. IV delivery modalities.
View Glutathione Guide →Clinical 72-hour harm-reduction protocol: immediate sensory de-escalation, supine cerebral reperfusion, cellular redox stabilization, and copyable emergency action card.
Read Crash Protocol →Interactive stopwatch assistant and diagnostic evaluator for orthostatic intolerance and POTS. Generates copyable clinical summaries formatted for physicians.
Launch Lean Test →Microglial TLR4 receptor antagonism, suppression of neuro-inflammation, morning vs. night dosing rules, and interactive micro-titration schedule calculator.
Explore LDN Guide →Comprehensive 3-tier testing checklist: core exclusions, EBV/HHV-6 pathogen serologies, NK cytotoxicity, and 1-click printable physician order sheet.
View Lab Checklist →Chronic Epstein-Barr Virus (EBV), enterovirus persistence in tissues, persistent SARS-CoV-2 antigen reservoirs, and Natural Killer (NK) cell cytotoxic suppression.
Explore Virology →HHV-6A/B neurotropism, central microglial activation, chromosomal integration (ciHHV-6), and Dr. Bhupesh Prusty's findings on mitochondrial fragmentation.
View HHV-6 Research →Diastolic cardiac dysfunction, left ventricular filling impairment, stroke volume reduction during upright posture, and cell-signaling peptide therapies.
View Cheney Archive →Longitudinal retrospective on documented recovery cases, realistic remission benchmarks (Bell Disability Scale), and multi-modal pacing frameworks.
Read Patient Trajectories →Post-viral mast cell hyper-reactivity, dual H1/H2 histamine blockade, natural/prescription mast cell stabilizers, and low-histamine dietary management.
Explore MCAS Protocol →Resia Pretorius research on fibrin amyloid microclots, capillary hypoperfusion, fluorescence microscopy, and comparison of fibrinolytic enzymes (Nattokinase / Lumbrokinase).
View Microclot Research →Targeted cellular bioenergetics: Ubiquinol CoQ10, Acetyl-L-Carnitine, D-Ribose, NAD+ precursors, and Magnesium Malate with interactive phase-gated titration planner.
View ATP Protocol →Predict PEM crashes 24–48 hours in advance using morning RMSSD baselines. Evidence-based transcutaneous auricular vagus nerve stimulation parameters to restore parasympathetic balance.
Launch HRV Forecaster →4-pillar hemodynamic management: high-sodium plasma volume expansion, WHO ORS osmolarity calculator, 30–40 mmHg abdominal compression, and targeted autonomic medications (Mestinon, Florinef).
Explore POTS Protocol →Mayo Clinic validated 31-question clinical instrument across 6 domains (Orthostatic, Vasomotor, GI, Bladder). Features an autonomic subtype differential engine (POTS vs OH vs Vasovagal Syncope).
Launch COMPASS-31 Screener →Cranial Nerve X neuromodulation: interactive 0.1 Hz resonant breathing metronome, emergency vasovagal syncope counter-maneuvers, left cymba conchae taVNS map, and clinical device reviews.
Launch Vagus Reset Protocol →Find vetted ME/CFS and dysautonomia specialists. Features an interactive 2015 IOM diagnostic criteria evaluator, ICD-10 medical billing code helper (G93.32), and printable physician intake dossier.
Launch Specialist Guide →Calculate your estimated anaerobic threshold heart rate using physiological 2-day CPET exercise guidelines from the Workwell Foundation. Setting continuous heart rate monitor alarms below this ceiling prevents cellular switch to anaerobic glycolysis and protects against multi-day Post-Exertional Malaise (PEM).
Deciphering why post-viral neuro-immune syndromes share identical physiological disruptions.
For decades, patients suffering from Myalgic Encephalomyelitis were frequently mischaracterized due to standard blood panels appearing normal. However, the surge in Post-Acute Sequelae of SARS-CoV-2 (Long COVID) has validated key physiological hallmarks first illuminated by ME/CFS citizen scientists and pioneering clinicians:
| Physiological Domain | Observed Dysfunction | Key Evidence & Biomarkers |
|---|---|---|
| Cellular Bioenergetics | Premature shift from oxidative phosphorylation to anaerobic glycolysis at minimal exertion. | Workwell 2-day CPET decline in VO2 peak, elevated ventricular lactate (PMID: 22438249). |
| Autonomic Regulation | Orthostatic Intolerance, POTS, and impaired cerebral blood flow during upright posture. | Tilt Table Testing, transcranial Doppler showing up to 30% reduction in cerebral perfusion (PMID: 32185448). |
| Immunological Exhaustion | Depressed Natural Killer (NK) cell cytotoxicity and autoantibodies against GPCR receptors. | Low perforin/granzyme expression; autoantibodies targeting β2-adrenergic and M3-acetylcholine receptors (PMID: 24700057). |
| Pathogen Persistence | Latent herpesvirus reactivation (EBV, HHV-6) and persistent viral RNA fragments in deep tissues. | Digital droplet PCR; biopsy confirmation in muscle, stomach, and vascular endothelium (PMID: 34220757). |
About ME/CFS was founded in the mid-2000s by citizen science pioneer Cort Johnson (later founder of Phoenix Rising and Health Rising) to bridge the vast chasm between laboratory discoveries and homebound patients. This restored 2026 archive ensures that foundational scientific data, clinical protocols, and disability guidance remain permanently open-access and citeable.
Comprehensive, peer-reviewed clinical monographs, treatment protocols, and diagnostic guides across the Myalgic Encephalomyelitis and Long COVID spectrum.