GPCR Autoantibodies in ME/CFS & POTS
Functional autoantibodies directed against Beta-2 adrenergic, Muscarinic M3/M4, and Angiotensin II type 1 receptors disrupting vascular tone and cardiac autonomic control.
Read Research Monograph →Deep-dive scientific monographs bridging foundational historical discoveries with modern post-viral immunology, vascular biology, neuro-endocrinology, and molecular genetics.
Functional autoantibodies directed against Beta-2 adrenergic, Muscarinic M3/M4, and Angiotensin II type 1 receptors disrupting vascular tone and cardiac autonomic control.
Read Research Monograph →The Resia Pretorius discovery: anomalous amyloid fibrinogen microclots and activated platelets entrapping pro-inflammatory cytokines and suffocating microvascular capillary oxygen delivery.
Read Research Monograph →Chronic viral persistence: Dr. John Chia's gastric biopsy enterovirus studies, the Incline Village outbreak history, and the molecular legacy of retroviral and HERV investigation.
Read Research Monograph →Human Herpesvirus 6A/6B and Epstein-Barr virus reactivation in lymphoid tissues and astrocytes, chromosomal integration (ciHHV-6), and mitochondrial fragmentation.
Read Research Monograph →Deciphering the 50% biological convergence: identical cellular hypoperfusion, mitochondrial metabolic collapse, mast cell activation, and dysautonomia post-SARS-CoV-2.
Read Research Monograph →Punch biopsy-proven loss of unmyelinated C-fibers and lightly myelinated A-delta fibers: the biological mechanism underpinning widespread neuropathic burning and vasomotor dysregulation.
Read Research Monograph →Atlantoaxial instability, pathological cranial settling, dynamic compression of the brainstem and vagus nerve, and surgical versus regenerative therapy indications.
Read Research Monograph →Spontaneous intracranial hypotension (SIH) mimicking POTS and ME/CFS: positional head pain, brain sag, epidural blood patches, and targeted dynamic CT myelography.
Read Research Monograph →Pathophysiology of preload failure: selective denervation of the splanchnic vascular bed causing blood to pool in abdominal viscera during upright posture, starving the cerebral cortex.
Read Research Monograph →Central hypothalamic CRH suppression, blunted ACTH response curves, diurnal cortisol flattening, and low DHEA production contributing to systemic hypocortisolism.
Read Research Monograph →Intestinal barrier breakdown, bacterial lipopolysaccharide (LPS) translocation into systemic blood, D-lactate producing bacteria, and small intestinal bacterial overgrowth.
Read Research Monograph →Chronic Inflammatory Response Syndrome (CIRS) per Dr. Ritchie Shoemaker: trichothecenes, ochratoxin A, low MSH, elevated TGF-beta1, and cholestyramine binder protocols.
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